- Graham Patrick Martin (Rusty Beck): Sharon Raydor's adoptive son, a former prostitute who witnessed Phillip Stroh burying a body. He has since started an investigative video blog called Identity and has started preparing for law school after finishing his journalism degree.
- Robert Gossett (Assistant Chief Russell Taylor): Director of Operations until Season 5 episode "White Lies, Part 1" when he was murdered in a courtroom shooting. He was then-Captain Raydor's first immediate supervisor when she assumed command of MCD. The former commanding officer of the Robbery-Homicide Division and later press liaison for the Major Crimes Division, Taylor long felt passed over and unappreciated by Chief Pope and the LAPD upper echelon command.
- Leonard Roberts (Assistant Chief Leo Mason): Director of Operations from Season 5 finale "Shockwave, Part 2" onward. He is Commander Raydor's immediate supervisor, with ideas about how to improve the Major Crimes Division. Mason was previously the Commander of the Criminal Intelligence Division.
- Jon Tenney (Deputy Chief Fritz Howard): Commanding officer of the Special Operations Bureau during Major Crimes (Season 3 episode "Sweet Revenge" onward). During The Closer and the first two and a half seasons of Major Crimes, he was a Special Agent for the F.B.I. and the liaison officer to the LAPD. Chief Howard served as the Acting Assistant Chief of Operations following Chief Taylor's murder ("White Lies, Part 1" to "Shockwave, Part 2").
- Mary McDonnell (Commander Sharon Raydor): The commanding officer of the Major Crimes Division. She was promoted from Captain to Commander in "Shockwave, Part 2" after being passed over at the time she assumed command of Major Crimes.
- GW Bailey (Lieutenant Louie Provenza): The division's senior member and Sharon's second-in-command. He is the immediate supervisor of the team in standard day-to-day-operations.
- Anthony Denison (Lieutenant Andy Flynn): Provenza's partner in the field.
- Michael Paul Chan (Lieutenant Michael Tao): The squad's forensics and technology expert; Tao previously was assigned to the LAPD's Scientific Investigation Division (SID).
- Raymond Cruz (Detective Julio Sanchez): The squad's gang and weapons expert, experience gained from his days on the LAPD's gang intelligence unit.
- Kearran Giovanni (Detective Amy Sykes): Transferred to the division from the Special Investigation Section, she is an expert on undercover operations. Sykes is a military veteran who served in Afghanistan.
- Daniel DiTomasso (Detective Wes Nolan): Transferred to the division from the Special Investigation Section after spending nearly six years undercover in a white supremacist gang. (Season 5, "White Lies, Part 3" onward).
- Phillip P. Keene (Civilian Surveillance Coordinator Buzz Watson): Buzz is the Scientific Investigation Division's civilian investigator assigned to the division. He is responsible for memorializing crime scenes, and managing technology in the field and in the squad's office. He also recently qualified as a LAPD reserve police officer.
- Jonathan Del Arco (Dr. Fernando Morales): A Los Angeles County Deputy Medical Examiner who coordinates with the team, conducting autopsies. Morales has a sharp medical mind and and equally sharp, sometimes sarcastic, wit. Morales is gay, and provides expertise on the gay community in Los Angeles.
- Ransford Doherty (Investigator Kendall): Kendall is responsible for examining the body at the crime scene and taking initial measurements, as well as preparing the body for transportation to the Los Angeles County Coroner's office.
- Kathe Mazur (Deputy District Attorney Andrea Hobbs): The DDA who works most frequently with Major Crimes, Hobbs is a team player.
- Nadine Velazquez (Deputy District Attorney Emma Rios): A new, inexperienced DDA under Hobbs' supervision, she is charged with preparing the case against Phillip Stroh (Season 2).
Recurring cast Edit
- Malcolm-Jamal Warner (Lieutenant Chuck Cooper): Lieutenant Cooper is the officer-in-charge of the Special Investigation Section (SIS) of the LAPD.
- Brandon Barash (Detective Robert Oderno): Robert Oderno is a detective in the LAPD's Missing Persons Unit.
- Rene Rosado (Gustavo Wallace): Gus Wallace is the older brother of murder victim Mariana Wallace. He is currently dating Rusty Beck.
- Camryn Manheim (Deputy Chief Winnie Davis): Chief Davis is the LAPD's Assistant Director of Operations.
- Ron Marasco (Judge Steven Grove): Steven Grove is a judge for the Superior Court of California.
- Steve Tom (Judge Craig Richwood): Craig Richwood is a judge for the Superior Court of California.
- Bill Brochtrup (Dr. Joe Bowman): Dr. Bowman is a psychologist who occasionally consults for the Los Angeles Police Department.